Changes and Correlations of the Intestinal Flora and Liver Metabolite Profiles in Mice With Gallstones.

ABSTRACT: There is increasing appreciation for the roles of the gut-liver axis in liver and gall diseases. Specific gut microbes are associated with susceptibility to gallstone diseases, while the relationship between intestinal flora and liver metabolism in the formation of gallstones remains unclear. In this study, an experimental group of model mice was given a lithogenic diet, and a control group was given a normal diet. Both groups were fed for 8 weeks. Integrating 16S rRNA gene sequencing and non-targeted metabolomics to explore the impact of the lithogenic diet on intestinal flora and liver metabolism, Spearman correlation analysis reveals the network of relationships between the intestine and liver. Our findings showed that the gut microbiome and liver metabolome compositions of the test gro

SUBMITTER: Chen Y 

PROVIDER: S-EPMC8416897 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature