Memory-like Differentiation Enhances NK Cell Responses to Melanoma.

ABSTRACT:

Purpose

Treatment of advanced melanoma is a clinical challenge. Natural killer (NK) cells are a promising cellular therapy for T cell-refractory cancers, but are frequently deficient or dysfunctional in patients with melanoma. Thus, new strategies are needed to enhance NK-cell antitumor responses. Cytokine-induced memory-like (ML) differentiation overcomes many barriers in the NK-cell therapeutics field, resulting in potent cytotoxicity and enhanced cytokine production against blood cancer targets. However, the preclinical activity of ML NK against solid tumors remains largely undefined.

Experimental design

Phenotypic and functional alterations of blood and advanced melanoma infiltrating NK cells were evaluated using mass cytometry. ML NK cells from healthy donors (HD) and p

SUBMITTER: Marin ND 

PROVIDER: S-EPMC8416927 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature