The Chronic Lymphocytic Leukemia Comorbidity Index (CLL-CI): A Three-Factor Comorbidity Model.

ABSTRACT:

Purpose

Comorbid medical conditions define a subset of patients with chronic lymphocytic leukemia (CLL) with poor outcomes. However, which comorbidities are most predictive remains understudied.

Experimental design

We conducted a retrospective analysis from 10 academic centers to ascertain the relative importance of comorbidities assessed by the cumulative illness rating scale (CIRS). The influence of specific comorbidities on event-free survival (EFS) was assessed in this derivation dataset using random survival forests to construct a CLL-specific comorbidity index (CLL-CI). Cox models were then fit to this dataset and to a single-center, independent validation dataset.

Results

The derivation and validation sets comprised 570 patients (59% receiving Bruton tyrosine k

SUBMITTER: Gordon MJ 

PROVIDER: S-EPMC8416936 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature