Emergence of a tet(M) Variant Conferring Resistance to Tigecycline in Streptococcus suis.

ABSTRACT: The aim of this study was to gain insight into the resistance determinants conferring resistance to tigecycline in Streptococcus (S.) suis and to investigate the genetic elements involved in their horizontal transfer. A total of 31 tetracycline-resistant S. suis isolates were screened for tigecycline resistance by broth microdilution. S. suis isolate SC128 was subjected to whole genome sequencing with particular reference to resistance determinants involved in tigecycline resistance. Transferability of genomic island (GI) GISsuSC128 was investigated by transformation. The roles of tet(L) or tet(M) in contributing to tigecycline resistance in S. suis were confirmed by transformation using different tet(L)- or tet(M

SUBMITTER: Yu R 

PROVIDER: S-EPMC8417041 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature