Naive Regulatory T Cell Subset Is Altered in X-Linked Agammaglobulinemia.

ABSTRACT: The interplay between T- and B-cell compartments during naïve, effector and memory T cell maturation is critical for a balanced immune response. Primary B-cell immunodeficiency arising from X-linked agammaglobulinemia (XLA) offers a model to explore B cell impact on T cell subsets, starting from the thymic selection. Here we investigated characteristics of naïve and effector T cell subsets in XLA patients, revealing prominent alterations in the corresponding T-cell receptor (TCR) repertoires. We observed immunosenescence in terms of decreased diversity of naïve CD4⁺ and CD8⁺ TCR repertoires in XLA donors. The most substantial alterations were found within naïve CD4⁺ subsets, and we have investigated these in greater detail. In particular, increased clonalit

SUBMITTER: Shelyakin PV 

PROVIDER: S-EPMC8417104 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature