Pituitary P62 deficiency leads to female infertility by impairing luteinizing hormone production.

ABSTRACT: P62 is a protein adaptor for various metabolic processes. Mice that lack p62 develop adult-onset obesity. However, investigations on p62 in reproductive dysfunction are rare. In the present study, we explored the effect of p62 on the reproductive system. P62 deficiency-induced reproductive dysfunction occurred at a young age (8 week old). Young systemic p62 knockout (p62^-/-) and pituitary-specific p62 knockout (p62^flox/flox αGSU^cre) mice both presented a normal metabolic state, whereas they displayed infertility phenotypes (attenuated breeding success rates, impaired folliculogenesis and ovulation, etc.) with decreased luteinizing hormone (LH) expression and production. Consistently, in an infertility model of polycystic ovary syndrome (PCOS), pituitary p62

SUBMITTER: Li X 

PROVIDER: S-EPMC8417229 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature