TIMELESS Promotes Tumor Progression by Enhancing Macrophages Recruitment in Ovarian Cancer.

ABSTRACT:

Objective

Ovarian cancer (OV) is the most fatal and frequent type of gynecological malignancy worldwide. TIMELESS (TIM), as a circadian clock gene, has been found to be highly expressed and predictive of poor prognosis in various cancers. However, the function of TIM in OV is not known. This study was designed to investigate the biological functions and underlying mechanisms of TIM during OV progression.

Methods

Cell viability assay, cell migration assay, immunohistochemistry staining, qPCR analyses, and tumor xenograft model were used to identify the functions of TIM in OV. Bioinformatics analyses, including GEPIA, cBioPortal, GeneMANIA, and TIMER, were used to analyze the gene expression, genetic alteration, and immune cell infiltration of TIM in OV.

Results

TIM is

SUBMITTER: Xing X 

PROVIDER: S-EPMC8417241 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature