Impact of Human Umbilical Cord Blood Mononuclear Cells on Gentamicin-Induced Renal Injury and Genotoxicity in Rats.

ABSTRACT: Background: Acute kidney injury (AKI), also known as acute renal failure (ARF), has received considerable critical attention in recent years. Gentamicin (GM) is an antibiotic whose prolonged use results in AKI with a high mortality rate. Methods: Fifty adult female albino rats weighing 150-200 g were used. The animals were divided into five groups: the first group was the normal healthy control one, the second group received only 1 × 10⁶ HUCB mononuclear cells (MNCs)/rat by intravenous (iv) injection, the third diseased group was given GM 100 mg/kg for 10 consecutive days by intraperitoneal injections, the fourth preventive group received 1 × 10⁶ HUCB MNCs/rat by iv injection 24 h before gentamicin treatment, and the fifth treated group received 1 × 10

SUBMITTER: Abu Almaaty AH 

PROVIDER: S-EPMC8417307 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature