Interactions Between Genes From Aging Pathways May Influence Human Lifespan and Improve Animal to Human Translation.

ABSTRACT: A major goal of aging research is identifying genetic targets that could be used to slow or reverse aging - changes in the body and extend limits of human lifespan. However, majority of genes that showed the anti-aging and pro-survival effects in animal models were not replicated in humans, with few exceptions. Potential reasons for this lack of translation include a highly conditional character of genetic influence on lifespan, and its heterogeneity, meaning that better survival may be result of not only activity of individual genes, but also gene-environment and gene-gene interactions, among other factors. In this paper, we explored associations of genetic interactions with human lifespan. We selected candidate genes from well-known aging pathways (IGF1/FOXO growth signaling, P53/P16 apo

SUBMITTER: Ukraintseva S 

PROVIDER: S-EPMC8417405 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature