Bioinspired particle engineering for non-invasive inhaled drug delivery to the lungs.

ABSTRACT: Pulmonary drug delivery is governed by several biophysical parameters of delivery carriers, such as particle size, shape, density, charge, and surface modifications. Although much attention has been given to other parameters, particle shape effects have rarely been explored. In this work, we assess the influence of particle shape of inhaled delivery carriers on their aerodynamic properties and macrophage uptake by using polymeric microparticles of different geometries ranging in various sizes. Doxorubicin was conjugated to the polymer particles and the bioconjugates were characterized. Interestingly, the results of in-vitro lung deposition, performed using a next generation impactor, demonstrated a significant improvement in the aerodynamic properties of the rod-shaped particles with a hig

SUBMITTER: Shukla SK 

PROVIDER: S-EPMC8417427 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature