Genetic Susceptibility to Fungal Infections and Links to Human Ancestry.

ABSTRACT: Over the ages, fungi have associated with different parts of the human body and established symbiotic associations with their host. They are mostly commensal unless there are certain not so well-defined factors that trigger the conversion to a pathogenic state. Some of the factors that induce such transition can be dependent on the fungal species, environment, immunological status of the individual, and most importantly host genetics. In this review, we discuss the different aspects of how host genetics play a role in fungal infection since mutations in several genes make hosts susceptible to such infections. We evaluate how mutations modulate the key recognition between the pathogen associated molecular patterns (PAMP) and the host pattern recognition receptor (PRR) molecules. We discuss

SUBMITTER: Naik B 

PROVIDER: S-EPMC8417537 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature