Use of X-Ray Fluorescence Microscopy for Studies on Research Models of Hepatocellular Carcinoma.

ABSTRACT: Introduction: TheraSphere^® microspheres containing yttrium ⁹⁰Y are among many radioembolization agents used clinically to reduce liver tumor burden, and their effects on cancer volume reduction are well-established. At the same time, concerns about off target tissue injury often limit their use. Deeper investigation into tissue distribution and long-term impact of these microspheres could inform us about additional ways to use them in practice. Methods: Healthy rat liver and rabbit liver tumor samples from animals treated with TheraSpheres were sectioned and their elemental maps were generated by X-ray fluorescence microscopy (XFM) at the Advanced Photon Source (APS) synchrotron at Argonne National Laboratory (ANL). Results: Elemental imaging allo

SUBMITTER: Paunesku T 

PROVIDER: S-EPMC8417723 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature