N⁶ -Methyladenosine Modification in Chronic Stress Response Due to Social Hierarchy Positioning of Mice.

ABSTRACT: Appropriately responding to stressful events is essential for maintaining health and well-being of any organism. Concerning social stress, the response is not always as straightforward as reacting to physical stressors, e.g., extreme heat, and thus has to be balanced subtly. Particularly, regulatory mechanisms contributing to gaining resilience in the face of mild social stress are not fully deciphered yet. We employed an intrinsic social hierarchy stress paradigm in mice of both sexes to identify critical factors for potential coping strategies. While global transcriptomic changes could not be observed in male mice, several genes previously reported to be involved in synaptic plasticity, learning, and anxiety-like behavior were differentially regulated in female mice. Moreover, changes in

SUBMITTER: Dos Santos Guilherme M 

PROVIDER: S-EPMC8417747 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature