A Complete and Low-Cost Cardiac Optical Mapping System in Translational Animal Models.

ABSTRACT: Clinicians, biologists, physicists, engineers, and computer scientists are coming together to better understand heart disease, which is currently the leading cause of death globally. Optical mapping, a high-speed fluorescence imaging technique that visualizes and measures key cardiac parameters such as action potentials, cytosolic calcium transients, and fibrillation dynamics, is a core research tool that has arisen from such interdisciplinary collaborations. In an effort to broaden its use, especially among clinical scientists and students, we developed a complete and low-cost optical mapping system, including a constant-flow Langendorff perfusion system, which minimizes the economic threshold to widespread use of this powerful tool in cardiac electrophysiology research. The system descri

SUBMITTER: Marina-Breysse M 

PROVIDER: S-EPMC8417781 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature