Nucleolipid Acid-Based Nanocarriers Restore Neuronal Lysosomal Acidification Defects.

ABSTRACT: Increasing evidence suggests that lysosomal dysfunction has a pathogenic role in neurodegenerative diseases. In particular, an increase in lysosomal pH has been reported in different cellular models of Parkinson's disease. Thus, targeting lysosomes has emerged as a promising approach. More specifically, regulating its pH could play a central role against the neurodegeneration process. To date, only a few agents specifically targeting lysosomal pH are reported in the literature, partly due to the challenge of crossing the Blood-Brain-Barrier (BBB), preventing drug penetration into the central nervous system (CNS). To develop chronic treatments for neurodegenerative diseases, crossing the BBB is crucial. We report herein the conception and synthesis of an innovative DNA derivative-based nano

SUBMITTER: Brouillard M 

PROVIDER: S-EPMC8417785 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature