Pro-Inflammatory Implications of 2-Hydroxypropyl-β-cyclodextrin Treatment.

ABSTRACT: Lifestyle- and genetically induced disorders related to disturbances in cholesterol metabolism have shown the detrimental impact of excessive cholesterol levels on a plethora of pathological processes such as inflammation. In this context, two-hydroxypropyl-β-cyclodextrin (CD) is increasingly considered as a novel pharmacological compound to decrease cellular cholesterol levels due to its ability to increase cholesterol solubility. However, recent findings have reported contra-indicating events after the use of CD questioning the clinical applicability of this compound. Given its potential as a therapeutic compound in metabolic inflammatory diseases, in this study, we evaluated the inflammatory effects of CD administration in the context of cholesterol-induced metabolic inflammation in

SUBMITTER: Houben T 

PROVIDER: S-EPMC8417873 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature