Defining a Methylation Signature Associated With Operational Tolerance in Kidney Transplant Recipients.

ABSTRACT: Operational tolerance after kidney transplantation is defined as stable graft acceptance without the need for immunosuppression therapy. However, it is not clear which cellular and molecular pathways are driving tolerance in these patients. We performed genome-wide analysis of DNA methylation in peripheral blood mononuclear cells from kidney transplant recipients with chronic rejection and operational tolerance from the Genetic Analysis of Molecular Biomarkers of Immunological Tolerance (GAMBIT) study. Our results showed that both clinical stages diverge in 2737 genes, indicating that each one has a specific methylation signature associated with transplant outcome. We also observed that tolerance is associated with demethylation in genes involved in immune function, including B and T cell

SUBMITTER: Rodriguez RM 

PROVIDER: S-EPMC8417883 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature