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A Novel Azaphilone Muyophilone A From the Endophytic Fungus Muyocopron laterale 0307-2.

ABSTRACT: Two known azaphilone derivatives, 4,6-dimethylcurvulinic acid (1) and austdiol (2), and their novel heterotrimer, muyophilone A (3), were isolated and identified from an endophytic fungus, Muyocopron laterale 0307-2. Their structures and stereochemistry were established by extensive spectroscopic analyses including HRMS, NMR spectroscopy, electronic circular dichroism (ECD) and vibrational circular dichroism (VCD) spectroscopic methods, as well as single crystal X-ray diffraction. In the structure of 3, two compound 2-derived azaphilone units were connected through an unprecedented five-membered carbon bridge which was proposed to be originated from compound 1. Compound 3 represents the first example of azaphilone heterotrimers.

SUBMITTER: Yuan C

PROVIDER: S-EPMC8417894 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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A Novel Azaphilone Muyophilone A From the Endophytic Fungus Muyocopron laterale 0307-2.

Yuan Chao C Guo Yuhua Y Wang Ke K Wang Zhunian Z Li Longfei L Zhu Huajie H Li Gang G

Frontiers in chemistry 20210824

Two known azaphilone derivatives, 4,6-dimethylcurvulinic acid (1) and austdiol (2), and their novel heterotrimer, muyophilone A (3), were isolated and identified from an endophytic fungus, Muyocopron laterale 0307-2. Their structures and stereochemistry were established by extensive spectroscopic analyses including HRMS, NMR spectroscopy, electronic circular dichroism (ECD) and vibrational circular dichroism (VCD) spectroscopic methods, as well as single crystal X-ray ...[more]

PMID: 34490216

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