Associations of Alcohol Consumption with Cardiovascular Disease-Related Proteomic Biomarkers: The Framingham Heart Study.

ABSTRACT:

Background

Alcohol consumption and cardiovascular disease (CVD) have a complex relation.

Objectives

We examined the associations between alcohol consumption, fasting plasma proteins, and CVD risk.

Methods

We performed cross-sectional association analyses of alcohol consumption with 71 CVD-related plasma proteins, and also performed prospective association analyses of alcohol consumption and protein concentrations with 3 CVD risk factors (obesity, hypertension, and diabetes) in 6745 Framingham Heart Study (FHS) participants (mean age 49 y; 53% women).

Results

A unit increase in log10 transformed alcohol consumption (g/d) was associated with an increased risk of hypertension (HR = 1.14; 95% CI: 1.04, 1.26; P = 0.007), and decreased risks of obesity (HR = 0.80; 95

SUBMITTER: Sun X 

PROVIDER: S-EPMC8417922 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature