Identification of Gut Microbiome Signatures in Patients With Post-stroke Cognitive Impairment and Affective Disorder.

ABSTRACT: Stroke (ST), endangering human health due to its high incidence and high mortality, is a global public health problem. There is increasing evidence that there is a link between the gut microbiota (GM) and neuropsychiatric diseases. We aimed to find the GM of ST, post-ST cognitive impairment (PSCI), and post-ST affective disorder (PSTD). GM composition was analyzed, followed by GM identification. Alpha diversity estimation showed microbiota diversity in ST patients. Beta diversity analysis showed that the bacterial community structure segregated differently between different groups. At the genus level, ST patients had a significantly higher proportion of Enterococcus and lower content of Bacteroides, Escherichia-Shigella, and Megamonas. PSCI patients had a significantly

SUBMITTER: Huang Y 

PROVIDER: S-EPMC8417941 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature