Stereotactic body radiotherapy for osseous low alpha-beta resistant metastases for pain relief-SOLAR-P.

ABSTRACT:

Background

Stereotactic Body Radiotherapy (SBRT) has shown effectiveness in treating bone metastases to alleviate pain. The benefit of SBRT may be further harnessed especially when radiating disease from primary malignancies with low alpha-beta ratios in order to maximize the magnitude and durability of pain relief. However, such an approach has not been studied in a prospective trial. We look to assess single-fraction SBRT for painful non-spinal bone metastases from radioresistant primaries.

Methods

Forty patients will be enrolled on an open label, phase II single arm trial to receive a single fraction of SBRT (15-20 Gray) to all sites of bone metastases requiring treatment for pain relief. Eligible patients will include those with primary malignancies consisting of prostat

SUBMITTER: Nguyen EK 

PROVIDER: S-EPMC8417953 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature