Molecular mechanism of Epicedium treatment for depression based on network pharmacology and molecular docking technology.

ABSTRACT:

Background

Increasing attention has been paid to the effect of Epimedium on the nervous system, particularly anti-depression function. In the present study, we applied network pharmacology to introduce a testable hypothesis on the multi-target mechanisms of Epicedium against depression.

Methods

By reconstructing the network of protein-protein interaction and drug-component-target, we predicted the key protein targets of Epicedium for the treatment of depression. Then, through molecular docking, the interaction of the main active components of Epicedium and predicted candidate targets were verified.

Results

Nineteen active compounds were selected from Epicedium. There were 200 targets associated with Epicedium and 537 targets related to depression. The key targets of E

SUBMITTER: Dong Y 

PROVIDER: S-EPMC8417989 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature