Preservation of satellite cell number and regenerative potential with age reveals locomotory muscle bias.

ABSTRACT:

Background

Although muscle regenerative capacity declines with age, the extent to which this is due to satellite cell-intrinsic changes vs. environmental changes has been controversial. The majority of aging studies have investigated hindlimb locomotory muscles, principally the tibialis anterior, in caged sedentary mice, where those muscles are abnormally under-exercised.

Methods

We analyze satellite cell numbers in 8 muscle groups representing locomotory and non-locomotory muscles in young and 2-year-old mice and perform transplantation assays of low numbers of hind limb satellite cells from young and old mice.

Results

We find that satellite cell density does not decline significantly by 2 years of age in most muscles, and one muscle, the masseter, shows a modest but

SUBMITTER: Arpke RW 

PROVIDER: S-EPMC8418011 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature