The microRNA miR-133b functions to slow Duchenne muscular dystrophy pathogenesis.

ABSTRACT:

Key points

Impairment of muscle biogenesis contributes to the progression of Duchenne muscular dystrophy (DMD). As a muscle enriched microRNA that has been implicated in muscle biogenesis, the role of miR-133b in DMD remains unknown. To assess miR-133b function in DMD-affected skeletal muscles, we genetically ablated miR-133b in the mdx mouse model of DMD. We show that deletion of miR-133b exacerbates the dystrophic phenotype of DMD-afflicted skeletal muscle by dysregulating muscle stem cells involved in muscle biogenesis, in addition to affecting signalling pathways related to inflammation and fibrosis. Our results provide evidence that miR-133b may underlie DMD pathology by affecting the proliferation and differentiation of muscle stem cells.

Abstract

Duchenne muscular dys

SUBMITTER: Taetzsch T 

PROVIDER: S-EPMC8418193 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature