Preoperative high-dose glucocorticoids for early recovery after liver resection: randomized double-blinded trial.

ABSTRACT:

Background

Glucocorticoids modulate the surgical stress response. Previous studies showed that high-dose preoperative glucocorticoids reduce levels of postoperative inflammatory markers and specific biomarkers of liver damage compared with placebo, and suggested a reduced complication rate and shorter hospital stay after liver surgery. However, there are no studies with a clinical primary outcome or of early recovery outcomes. The aim of this study was to investigate whether a single high dose of preoperative glucocorticoid reduces complications in the immediate postoperative phase after liver surgery.

Methods

This was a single-centre, double-blinded, parallel-group RCT investigating preoperative methylprednisolone 10 mg/kg (high dose) versus dexamethasone 8 mg (standard-dos

SUBMITTER: Steinthorsdottir KJ 

PROVIDER: S-EPMC8418207 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature