Innate immune memory is associated with increased disease-free survival in bladder cancer patients treated with bacillus Calmette-Guerin.

ABSTRACT:

Introduction

While studies suggest that innate immune memory acquired by circulating monocytes may mediate the benefit of bacillus Calmette-Guérin (BCG) in the treatment of patients with high-risk non-muscle-invasive bladder cancer (NMIBC), prospective studies are lacking. Innate immune memory is defined by enhanced release of pro-inflammatory cytokines by innate immune cells following a secondary challenge with pattern recognition receptor (PRR) ligands.

Methods

Peripheral blood monocytes isolated from 33 patients with intermediate- or high-risk NMIBC before and after two or five induction BCG instillations were stimulated with the PRR ligand lipopolysaccharide (LPS). Inflammatory cytokine levels in the culture medium were measured. Extent of innate immune memory acquisitio

SUBMITTER: Graham CH 

PROVIDER: S-EPMC8418256 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature