Patterns of multimorbidity and risk of severe SARS-CoV-2 infection: an observational study in the U.K.

ABSTRACT:

Background

Pre-existing comorbidities have been linked to SARS-CoV-2 infection but evidence is sparse on the importance and pattern of multimorbidity (2 or more conditions) and severity of infection indicated by hospitalisation or mortality. We aimed to use a multimorbidity index developed specifically for COVID-19 to investigate the association between multimorbidity and risk of severe SARS-CoV-2 infection.

Methods

We used data from the UK Biobank linked to laboratory confirmed test results for SARS-CoV-2 infection and mortality data from Public Health England between March 16 and July 26, 2020. By reviewing the current literature on COVID-19 we derived a multimorbidity index including: (1) angina; (2) asthma; (3) atrial fibrillation; (4) cancer; (5) chronic kidney disease;

SUBMITTER: Chudasama YV 

PROVIDER: S-EPMC8418288 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature