Epigenetics Is Implicated in the Basis of Gender Incongruence: An Epigenome-Wide Association Analysis.

ABSTRACT:

Introduction

The main objective was to carry out a global DNA methylation analysis in a population with gender incongruence before gender-affirming hormone treatment (GAHT), in comparison to a cisgender population.

Methods

A global CpG (cytosine-phosphate-guanine) methylation analysis was performed on blood from 16 transgender people before GAHT vs. 16 cisgender people using the Illumina© Infinium Human Methylation 850k BeadChip, after bisulfite conversion. Changes in the DNA methylome in cisgender vs. transgender populations were analyzed with the Partek^® Genomics Suite program by a 2-way ANOVA test comparing populations by group and their sex assigned at birth.

Results

The principal components analysis (PCA) showed that both populations (cis and trans) di

SUBMITTER: Ramirez K 

PROVIDER: S-EPMC8418298 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature