BMP receptor blockade overcomes extrinsic inhibition of remyelination and restores neurovascular homeostasis.

ABSTRACT: Extrinsic inhibitors at sites of blood-brain barrier disruption and neurovascular damage contribute to remyelination failure in neurological diseases. However, therapies to overcome the extrinsic inhibition of remyelination are not widely available and the dynamics of glial progenitor niche remodelling at sites of neurovascular dysfunction are largely unknown. By integrating in vivo two-photon imaging co-registered with electron microscopy and transcriptomics in chronic neuroinflammatory lesions, we found that oligodendrocyte precursor cells clustered perivascularly at sites of limited remyelination with deposition of fibrinogen, a blood coagulation factor abundantly deposited in multiple sclerosis lesions. By developing a screen (OPC-X-screen) to identify compounds that promote remyelinat

SUBMITTER: Petersen MA 

PROVIDER: S-EPMC8418337 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature