Early-Onset Pancreas Cancer: Clinical Descriptors, Genomics, and Outcomes.

ABSTRACT:

Background

Recent evidence suggests a rising incidence of cancer in younger individuals. Herein, we report the epidemiologic, pathologic, and molecular characteristics of a patient cohort with early-onset pancreas cancer (EOPC).

Methods

Institutional databases were queried for demographics, treatment history, genomic results, and outcomes. Overall survival from date of diagnosis was estimated using Kaplan-Meier method.

Results

Between 2008 and 2018, 450 patients with EOPC were identified at Memorial Sloan Kettering. Median overall survival was 16.3  (95% confidence interval [CI] = 14.6 to 17.7) months in the entire cohort and 11.3  (95% CI = 10.2 to 12.2) months for patients with stage IV disease at diagnosis. Of the patients, 132 (29.3% of the cohort) underwent somat

SUBMITTER: Varghese AM 

PROVIDER: S-EPMC8418394 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature