Dataset Information

Early-Onset Pancreas Cancer: Clinical Descriptors, Genomics, and Outcomes.

ABSTRACT:

Background

Recent evidence suggests a rising incidence of cancer in younger individuals. Herein, we report the epidemiologic, pathologic, and molecular characteristics of a patient cohort with early-onset pancreas cancer (EOPC).

Methods

Institutional databases were queried for demographics, treatment history, genomic results, and outcomes. Overall survival from date of diagnosis was estimated using Kaplan-Meier method.

Results

Between 2008 and 2018, 450 patients with EOPC were identified at Memorial Sloan Kettering. Median overall survival was 16.3 (95% confidence interval [CI] = 14.6 to 17.7) months in the entire cohort and 11.3 (95% CI = 10.2 to 12.2) months for patients with stage IV disease at diagnosis. Of the patients, 132 (29.3% of the cohort) underwent somatic testing; 21 of 132 (15.9%) had RAS wild-type cancers with identification of several actionable alterations, including ETV6-NTRK3, TPR-NTRK1, SCLA5-NRG1, and ATP1B1-NRG1 fusions, IDH1 R132C mutation, and mismatch repair deficiency. A total of 138 patients (30.7% of the cohort) underwent germline testing; 44 of 138 (31.9%) had a pathogenic germline variant (PGV), and 27.5% harbored alterations in cancer susceptibility genes. Of patients seen between 2015 and 2018, 30 of 193 (15.5%) had a PGV. Among 138 who underwent germline testing, those with a PGV had a reduced all-cause mortality compared with patients without a PGV controlling for stage and year of diagnosis (hazard ratio = 0.42, 95% CI = 0.26 to 0.69).

Conclusions

PGVs are present in a substantial minority of patients with EOPC. Actionable somatic alterations were identified frequently in EOPC, enriched in the RAS wild-type subgroup. These observations underpin the recent guidelines for universal germline testing and somatic profiling in pancreatic ductal adenocarcinoma.

SUBMITTER: Varghese AM

PROVIDER: S-EPMC8418394 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Publications

Early-Onset Pancreas Cancer: Clinical Descriptors, Genomics, and Outcomes.

Varghese Anna M AM Singh Isha I Singh Rituraj R Kunte Siddharth S Chou Joanne F JF Capanu Marinela M Wong Winston W Lowery Maeve A MA Stadler Zsofia K ZK Salo-Mullen Erin E Saadat Lily V LV Wei Alice C AC Reyngold Marsha M Basturk Olca O Benayed Ryma R Mandelker Diana D Iacobuzio-Donahue Christine A CA Kelsen David P DP Park Wungki W Yu Kenneth H KH O'Reilly Eileen M EM

Journal of the National Cancer Institute 20210901 9

<h4>Background</h4>Recent evidence suggests a rising incidence of cancer in younger individuals. Herein, we report the epidemiologic, pathologic, and molecular characteristics of a patient cohort with early-onset pancreas cancer (EOPC).<h4>Methods</h4>Institutional databases were queried for demographics, treatment history, genomic results, and outcomes. Overall survival from date of diagnosis was estimated using Kaplan-Meier method.<h4>Results</h4>Between 2008 and 2018, 450 patients with EOPC w ...[more]

PMID: 33755158

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Dataset Information

Early-Onset Pancreas Cancer: Clinical Descriptors, Genomics, and Outcomes.

Background

Methods

Results

Conclusions

Publications

Early-Onset Pancreas Cancer: Clinical Descriptors, Genomics, and Outcomes.

Similar Datasets

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