Evaluating Polygenic Risk Scores for Breast Cancer in Women of African Ancestry.

ABSTRACT:

Background

Polygenic risk scores (PRSs) have been demonstrated to identify women of European, Asian, and Latino ancestry at elevated risk of developing breast cancer (BC). We evaluated the performance of existing PRSs trained in European ancestry populations among women of African ancestry.

Methods

We assembled genotype data for women of African ancestry, including 9241 case subjects and 10 193 control subjects. We evaluated associations of 179- and 313-variant PRSs with overall and subtype-specific BC risk. PRS discriminatory accuracy was assessed using area under the receiver operating characteristic curve. We also evaluated a recalibrated PRS, replacing the index variant with variants in each region that better captured risk in women of African ancestry and estimated life

SUBMITTER: Du Z 

PROVIDER: S-EPMC8418423 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature