Comparative analysis of the association between various serum vitamin D biomarkers and sarcopenia.

ABSTRACT:

Background

Vitamin D status is associated with muscle strength and maintenance of muscle fibers. However, which serum vitamin D biomarker better reflects sarcopenia remains unclear. The aim of this study was to investigate associations between various serum vitamin D biomarkers (total 25-hydroxy vitamin D [25(OH)D], bioavailable 25(OH)D, 24,25-dihydroxyvitamin D [24,25(OH)₂ D], and vitamin D metabolite ratio [VMR]) and sarcopenia.

Methods

The data for 83 hip fracture patients were finally included in the analysis. Sarcopenia was defined according to the Asia Working Group for Sarcopenia (AWGS) criteria. Measurements of 24,25(OH)₂ D and 25(OH)D were made using solid-phase extraction (SPE) and subsequent liquid chromatography-tandem mass spectrometry (LC-

SUBMITTER: Yoo JI 

PROVIDER: S-EPMC8418464 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature