CircRNAs as promising biomarker in diagnosis of breast cancer: An updated meta-analysis.

ABSTRACT:

Background

Circular RNAs (circRNAs) have been identified to be involved in onset and progression of multiple malignant tumors. The present study aimed to systematically evaluate the diagnostic values of circRNAs in breast cancer.

Methods

The PubMed, Web of Science, Embase, CNKI, and Wanfang online databases were searched for the relevant studies before December 31, 2020. Statistical analysis of the diagnostic tests was performed based on STATA 16.0, Meta-DiSc 1.4, and RevMan 5.3 software. The threshold effect and publication bias were measured by the Spearman correlation and Deeks' funnel plot asymmetry test, respectively.

Results

Twenty-one studies from 13 articles were included in this meta-analysis. The pooled sensitivity and specificity were 0.77 and 0.71, respect

SUBMITTER: Chu M 

PROVIDER: S-EPMC8418489 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature