Effects of m6A RNA methylation regulators on endometrial cancer.

ABSTRACT:

Background

The modification 6-methyladenine (m⁶ A) is the most common type in RNA methylation. Our study aims to explore the bioinformatic analysis of m⁶ A in endometrial cancer.

Methods

The expression of 23 m⁶ A RNA methylation regulators was compared through The Cancer Genome Atlas (TCGA) database among 406 endometrial tissue and 19 normal tissue samples. The Wilcoxon test was applied to compare the relationship between the clinicopathological characteristics and expression. Cox regressions were performed to identify the prognostic factors associated with overall survival. Gene ontology (GO) and Gene Set Enrichment Analysis (GSEA) were performed to evaluate the potential pathways.

Results

YTHDF2, HNRNPA2B1, HDRNPA2B1, YTHDF1, FMR1, I

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8418492 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature