Elevated serum eotaxin and IP-10 levels as potential biomarkers for the detection of esophageal squamous cell carcinoma.

ABSTRACT:

Background and aims

Esophageal squamous cell cancer (ESCC) is one of the leading malignant cancers with a high incidence and mortality. Exploring novel serum biomarkers will help improve the management and monitoring of ESCC.

Methods

In the present study, we first used a ProcartaPlex Array to screen for serum proteins that were increased in 40 ESCC patients compared with matched normal controls; we found that eight proteins (IL-2, IL-5, IP-10, IL-8, eotaxin, TNF-α, HGF, and MIP-1b) had higher serum levels in ESCC patients than in normal controls. We further verified the clinical relevance of the candidate biomarkers with a larger sample of sera.

Results

In the 174 tested ESCC patients and 189 normal controls, the serum levels of eotaxin and IP-10 were significantly hi

SUBMITTER: Chang C 

PROVIDER: S-EPMC8418505 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature