The effect of oral and intravenous antimicrobials on pulmonary exacerbation recovery in cystic fibrosis.

ABSTRACT:

Background

Retrospective studies indicate that more cystic fibrosis (CF) pulmonary exacerbations (PEx) are treated with oral (PO) than with intravenous (IV) antimicrobials despite little knowledge of the relative effects of PO treatment on lung function recovery or long-term impacts on lung disease progression. Previous studies have suggested that PO treatment may be associated with slower lung function recovery compared with IV treatment. We used longitudinal home spirometry data from the eICE study (NCT01104402) to compare PO versus IV antimicrobial treatment responses for PEx diagnosed by home spirometry and symptom assessment.

Methods

Adolescent and adult eICE participants performed home spirometry twice weekly for one year. PEx were diagnosed by a protocol-defined algor

SUBMITTER: VanDevanter EJ 

PROVIDER: S-EPMC8418627 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature