A Novel Chimeric Antigen as a Vaccine Candidate against Leishmania major: In silico Analysis.

ABSTRACT:

Background

Leishmania is a mandatory intracellular pathogen and causing neglected disease. Hence, protection against leishmaniasis by a development vaccine is an important subject. This study aimed to design a poly-epitope vaccine for cutaneous leishmaniasis.

Methods

The present study was conducted in the Parasitology Department of Tarbiat Modares University, Tehran, Iran during 2017-2019. Several bioinformatics methods at online servers were used for prediction of different aspects of poly-epitope, including, physico-chemical attributes, allergenicity, antigenicity, secondary and tertiary structures, B-cell, T-cell and MHC (I, II) potential epitopes of LACK, LEIF, GP63 and SMT antigens of L. major.

Results

After designing the construct (GLSL), the outpu

SUBMITTER: Ahmadpour NB 

PROVIDER: S-EPMC8418661 | biostudies-literature | 2021 Apr-Jun

REPOSITORIES: biostudies-literature