Development of theranostic dual-layered Au-liposome for effective tumor targeting and photothermal therapy.

ABSTRACT:

Background

Photothermal therapy (PTT) is an emerging anti-cancer therapeutic strategy that generates hyperthermia to ablate cancer cells under laser irradiation. Gold (Au) coated liposome (AL) was reported as an effective PTT agent with good biocompatibility and excretory property. However, exposed Au components on liposomes can cause instability in vivo and difficulty in further functionalization.

Results

Herein, we developed a theranostic dual-layered nanomaterial by adding liposomal layer to AL (LAL), followed by attaching polyethylene glycol (PEG) and radiolabeling. Functionalization with PEG improves the in vivo stability of LAL, and radioisotope labeling enables in vivo imaging of LAL. Functionalized LAL is stable in physiological conditions, and ⁶⁴Cu labele

SUBMITTER: Jeon M 

PROVIDER: S-EPMC8418714 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature