SPECT imaging of pulmonary vascular disease in bleomycin-induced lung fibrosis using a vascular endothelium tracer.

ABSTRACT:

Background

Pulmonary hypertension (PH) complicating idiopathic pulmonary fibrosis (IPF) is associated to worse outcome. There is a great need for a non-invasive diagnostic modality to detect and evaluate the severity of pulmonary vascular disease (PVD). ^99mTc-PulmoBind is a novel imaging agent that binds to the adrenomedullin (AM) receptor on the pulmonary microvascular endothelium. SPECT imaging employing the endothelial cell tracer ^99mTc-PulmoBind was used to assess PVD associated with lung fibrosis.

Methods

Rats with selective right lung bleomycin-induced fibrosis were compared to control rats. SPECT imaging was performed after three weeks with ^99mTc-PulmoBind and ^99mTc-macroaggregates of albumin (MAA). PH and right ventricular

SUBMITTER: Harel F 

PROVIDER: S-EPMC8418741 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature