Investigation of Genes Associated With Atherosclerosis in Patients With Systemic Lupus Erythematosus.

ABSTRACT:

Objectives

In this study, we aimed to identify patients with systemic lupus erythematosus (SLE) who are genetically at risk for developing atherosclerosis.

Patients and methods

Between November 2014 and May 2016, a total of 38 patients with SLE (36 females, 2 males; mean age: 37.6 years; range, 18 to 71 years) and 32 healthy females (mean age: 31.5 years; range, 19 to 54 years) were included in the study. Carotid intima-media thickness (CIMT) was measured using high-resolution B-mode ultrasonography. SurePrint G3 Human Gene Expression 8x60K Microarray kit was used in our study. Genes showing differences in expression between the groups were identified by using GeneSpring GX 10.0 program. Pathway analyses of gene expressions were performed using Ingenuity Pathways Analysis (I

SUBMITTER: Balci MA 

PROVIDER: S-EPMC8418757 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature