Molecular classification and therapeutic targets in extrahepatic cholangiocarcinoma.

ABSTRACT:

Background & aims

Cholangiocarcinoma (CCA), a deadly malignancy of the bile ducts, can be classified based on its anatomical location into either intrahepatic (iCCA) or extrahepatic (eCCA), each with different pathogenesis and clinical management. There is limited understanding of the molecular landscape of eCCA and no targeted therapy with clinical efficacy has been approved. We aimed to provide a molecular classification of eCCA and identify potential targets for molecular therapies.

Methods

An integrative genomic analysis of an international multicenter cohort of 189 eCCA cases was conducted. Genomic analysis included whole-genome expression, targeted DNA-sequencing and immunohistochemistry. Molecular findings were validated in an external set of 181 biliary tract tumors

SUBMITTER: Montal R 

PROVIDER: S-EPMC8418904 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature