SARS-CoV-2 sculpts the immune system to induce sustained virus-specific naive-like and memory B-cell responses.

ABSTRACT:

Objectives

SARS-CoV-2 infection induces virus-reactive memory B cells expressing unmutated antibodies, which hints at their emergence from naïve B cells. Yet, the dynamics of virus-specific naïve B cells and their impact on immunity and immunopathology remain unclear.

Methods

We longitudinally profiled SARS-CoV-2-specific B-cell responses in 25 moderate-to-severe COVID-19 patients by high-dimensional flow cytometry and isotyping and subtyping ELISA. We also explored the relationship of B-cell responses to SARS-CoV-2 with the activation of effector and regulatory cells from the innate or adaptive immune system.

Results

We found a virus-specific antibody response with a broad spectrum of classes and subclasses during acute infection, which evolved into an IgG1-dominated

SUBMITTER: de Campos-Mata L 

PROVIDER: S-EPMC8418925 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature