Sex differences and similarities in the neuroimmune response to central administration of poly I:C.

ABSTRACT:

Background

The neuroimmune system is required for normal neural processes, including modulation of cognition, emotion, and adaptive behaviors. Aberrant neuroimmune activation is associated with dysregulation of memory and emotion, though the precise mechanisms at play are complex and highly context dependent. Sex differences in neuroimmune activation and function further complicate our understanding of its roles in cognitive and affective regulation.

Methods

Here, we characterized the physiological sickness and inflammatory response of the hippocampus following intracerebroventricular (ICV) administration of a synthetic viral mimic, polyinosinic:polycytidylic acid (poly I:C), in both male and female C57Bl/6N mice.

Results

We observed that poly I:C induced weight loss,

SUBMITTER: Posillico CK 

PROVIDER: S-EPMC8418962 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature