Inhibiting microglia proliferation after spinal cord injury improves recovery in mice and nonhuman primates.

ABSTRACT: No curative treatment is available for any deficits induced by spinal cord injury (SCI). Following injury, microglia undergo highly diverse activation processes, including proliferation, and play a critical role on functional recovery. In a translational objective, we investigated whether a transient pharmacological reduction of microglia proliferation after injury is beneficial for functional recovery after SCI in mice and nonhuman primates. Methods: The colony stimulating factor-1 receptor (CSF1R) regulates proliferation, differentiation, and survival of microglia. We orally administrated GW2580, a CSF1R inhibitor that inhibits microglia proliferation. In mice and nonhuman primates, we then analyzed treatment outcomes on locomotor function and spinal cord pathology. Finally, we us

SUBMITTER: Poulen G 

PROVIDER: S-EPMC8419033 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature