A tumor microenvironment responsive nanosystem for chemodynamic/chemical synergistic theranostics of colorectal cancer.

ABSTRACT: Rationale: The synergism of new modalities alongside chemodynamic therapy into common chemotherapy has shown promising potential in clinical applications. This paper reports a tumor microenvironment-responsive nanosystem for chemodynamic/chemical synergistic therapy and magnetic resonance imaging (MRI). Methods: The biodegradable nanosystem is synthesized using a surface-modified chain transfer agent for surface-initiated living radical polymerization of the chemotherapeutic drug. Results: In this nanosystem, named CAMNSN@PSN38, the cycling time and solubility of the chemotherapeutic drug are improved. The nanoparticles delivered to tumor tissues gradually release the chemotherapeutic drug and Mn²⁺ through glutathione (GSH)-triggered biodegradation in the tu

SUBMITTER: Wang L 

PROVIDER: S-EPMC8419042 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature