A Prospective Investigation of Circulating Metabolome Identifies Potential Biomarkers for Gastric Cancer Risk.

ABSTRACT:

Background

Metabolomics is widely used to identify potential novel biomarkers for cancer risk. No investigation, however, has been conducted to prospectively evaluate the role of perturbation of metabolome in gastric cancer development.

Methods

250 incident cases diagnosed with primary gastric cancer were selected from the Shanghai Women's Health and the Shanghai Men's Health Study, and each was individually matched to one control by incidence density sampling. An untargeted global profiling platform was used to measure approximately 1,000 metabolites in prediagnostic plasma. Conditional logistic regression was utilized to generate ORs and P values.

Results

Eighteen metabolites were associated with gastric cancer risk at P < 0.01. Among them, 11 metaboli

SUBMITTER: Shu X 

PROVIDER: S-EPMC8419074 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature