Prolactin and Risk of Epithelial Ovarian Cancer.

ABSTRACT:

Background

Prolactin is synthesized in the ovaries and may play a role in ovarian cancer etiology. One prior prospective study observed a suggestive positive association between prolactin levels and risk of ovarian cancer.

Methods

We conducted a pooled case-control study of 703 cases and 864 matched controls nested within five prospective cohorts. We used unconditional logistic regression to calculate adjusted odds ratios (OR) and 95% confidence intervals (CI) for the association between prolactin and ovarian cancer risk. We examined heterogeneity by menopausal status at blood collection, body mass index (BMI), age, and histotype.

Results

Among women with known menopausal status, we observed a positive trend in the association between prolactin and ovarian cancer risk

SUBMITTER: Hathaway CA 

PROVIDER: S-EPMC8419083 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature