Interaction of micropatterned topographical and biochemical cues to direct neurite growth from spiral ganglion neurons.

ABSTRACT: Functional outcomes with neural prosthetic devices, such as cochlear implants, are limited in part due to physical separation between the stimulating elements and the neurons they stimulate. One strategy to close this gap aims to precisely guide neurite regeneration to position the neurites in closer proximity to electrode arrays. Here, we explore the ability of micropatterned biochemical and topographic guidance cues, singly and in combination, to direct the growth of spiral ganglion neuron (SGN) neurites, the neurons targeted by cochlear implants. Photopolymerization of methacrylate monomers was used to form unidirectional topographical features of ridges and grooves in addition to multidirectional patterns with 90^o angle turns. Microcontact printing was also used to create si

SUBMITTER: Truong K 

PROVIDER: S-EPMC8419132 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature