Risk of antibiotic treatment failure in premenopausal women with uncomplicated urinary tract infection.

ABSTRACT:

Purpose

Acute uncomplicated urinary tract infections (UTIs) are among the most common indications for antibiotic prescriptions in otherwise healthy women. We compared the risk of treatment failure of antibiotic regimens for outpatient treatment of UTI in real-world practice.

Methods

We identified non-pregnant, premenopausal women diagnosed with uncomplicated, lower tract UTI and prescribed an oral antibiotic with activity against common uropathogens. We used propensity score-weighted Kaplan-Meier functions to estimate 30-day risks and risk differences (RD) for pyelonephritis and UTI-related antibiotic prescription switch.

Results

Of 1 140 602 patients, the distribution of index prescriptions was 44% fluoroquinolones (non-first-line), 28% trimethoprim-sulfamethoxazole

SUBMITTER: Butler AM 

PROVIDER: S-EPMC8419150 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature