Network analysis and the impact of Aflibercept on specific mediators of angiogenesis in HUVEC cells.

ABSTRACT: Angiogenesis, inflammation and endothelial cells' migration and proliferation exert fundamental roles in different diseases. However, more studies are needed to identify key proteins and pathways involved in these processes. Aflibercept has received the approval of the US Food and Drug Administration (FDA) for the treatment of wet AMD and colorectal cancer. Moreover, the effect of Aflibercept on VEGFR2 downstream signalling pathways has not been investigated yet. Here, we integrated text mining data, protein-protein interaction networks and multi-experiment microarray data to specify candidate genes that are involved in VEGFA/VEGFR2 signalling pathways. Network analysis of candidate genes determined the importance of the nominated genes via different centrality parameters. Thereupon, sever

SUBMITTER: Latifi-Navid H 

PROVIDER: S-EPMC8419159 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature